Combination therapy

Combination therapy is an increasingly important strategy in modern medicine, especially for complex diseases such as cancer, autoimmune disorders, and chronic infections. By simultaneously targeting multiple pathways or mechanisms of disease progression, combination therapy can enhance therapeutic efficacy, reduce the likelihood of resistance, and lower the required doses of individual agents thereby minimizing side effects. Advances in proteomic technologies like Reverse Phase Protein Microarrays (RPPA) have made it possible to monitor the molecular impact of combination treatments across hundreds of signaling proteins and post-translational modifications in patient-derived samples. This systems-level view helps researchers identify synergistic drug interactions, predict biomarkers of response, and optimize personalized treatment regimens. As our understanding of molecular networks deepens, combination therapy stands as a cornerstone of precision medicine.