Laser Capture Microdissection

Theranostics Health utilizes Laser Capture Microdissection (LCM) to isolate purified or enriched populations of cells from heterogeneous tissue samples. When LCM and RPMA technologies are employed in an integrated manner, one can approach the specificity of conventional immunochemistry analysis (via LCM) while capitalizing on the high throughput proteomic pathway analysis capabilities that the RPMA platform offers for analyzing preclinical and clinical tissue samples.

Typically, only one to a few tissue sections from a core needle biopsy are required to analyze the tens of RPMA-based assays needed to quantitatively measure the presence and activation status of a given drug target, its downstream pathway, as well as potential compensatory or survival pathways.

Proteomic analysis services that utilize our LCM capabilities can be performed on either frozen or formalin-fixed, paraffin-embedded (FFPE) tissue samples, and are performed under the supervision of Theranostics Health’s in-house, board-certified pathologist.